| Rd. (pick No.) | Player | Pos. | School | Birthday | B | T | Ht. | Wt. |
| 1 (13) | Tyler Colvin | OF | Clemson University (SC) | 9/5/85 | L | L | 6-3 | 190 |
| 5 (149) | Jeffrey Samardzija | RHP | University of Notre Dame (IN) | 1/23/85 | R | R | 6-6 | 215 |
| 6 (179) | Joshua Lansford | 3B | Cal Poly San Luis Obispo (CA) | 7/31/84 | R | R | 6-2 | 220 |
| 7 (209) | Steven Clevenger | SS | Chipola J.C. (MD) | 4/5/86 | L | R | 6-0 | 185 |
| 8 (239) | William Muldowney | RHP | University of Pittsburgh (PA) | 8/9/84 | R | R | 6-1 | 205 |
| 9 (269) | Clifford Andersen | CF | Cottonwood Senior H.S. (UT) | 7/24/87 | L | L | 6-2 | 185 |
| 10 (299) | Jacob Renshaw | RHP | Ventura College (CA) | 4/29/86 | R | R | 6-2 | 195 |
| 11 (329) | Christopher Huseby | RHP | Martin County H.S. (FL) | 1/11/88 | R | R | 6-7 | --- |
| 12 (359) | Kitt Kopach | RHP | Illinois State University | 2/14/85 | L | R | 6-2 | 195 |
| 13 (389) | Matthew Camp | CF | North Carolina State | 5/29/84 | L | R | 6-0 | 190 |
| 14 (419) | Andrew Rundle | CF | Bend Senior H.S. (OR) | 11/5/87 | L | L | 6-4 | 180 |
| 15 (449) | Matthew Canepa | C | Cal Poly San Luis Obispo (CA) | 6/3/85 | R | R | 6-1 | 195 |
| 16 (479) | Richard Parker | C | U of Arkansas Fayetteville | 6/19/85 | R | R | 6-3 | 220 |
| 17 (509) | Keoni Ruth | 2B | U of San Diego (CA) | 3/21/85 | R | R | 5-11 | 200 |
| 18 (539) | Jose Hernandez | RHP | Edgewater H.S. (HI) | 2/27/88 | R | R | 6-2 | 190 |
| 19 (569) | Jeremy Papelbon | LHP | U of North Florida | 6/24/83 | L | L | 6-1 | 205 |
| 20 (599) | Kevin Kreier | RHP | Foothill High School (NV) | 8/31/87 | R | R | 6-4 | --- |
| 21 (629) | Taylor Parker | LHP | U of Missouri - Columbia | 10/2/84 | L | L | 5-10 | 155 |
| 22 (659) | Jovan Rosa | 3B | Lake City C.C. (CT) | 10/26/87 | R | R | 6-2 | 180 |
| 23 (689) | Charles Platt | RHP | Lamar University (TX) | 10/12/82 | R | R | 6-2 | 235 |
| 24 (719) | Matt Matulia | SS | The Citadel (FL) | 5/24/84 | S | R | 6-0 | 186 |
| 25 (749) | Jamie Bagley | RHP | Hargrave H.S. (TX) | 7/16/87 | R | R | 6-3 | 205 |
| 26 (779) | Michael Cooper | RHP | U.C. Berkeley (CA) | 1/29/84 | R | R | 6-5 | 235 |
| 27 (809) | Cedric Redmond | RHP | Joliet Township H.S. (IL) | 8/30/88 | S | R | 6-1 | 175 |
| 28 (839) | Brett Summers | RHP | South Suburban College (IN) | 3/26/87 | R | R | 6-6 | 195 |
| 29 (869) | Jordan Latham | RHP | C of Southern Idaho | 9/25/86 | R | R | 6-2 | 180 |
| 30 (899) | Donald Walters | RHP | Richland College (TX) | 7/18/86 | R | R | 6-1 | 195 |
| 31 (929) | Bryan Collins | RHP | Alvin C.C. (TX) | 9/10/84 | R | R | 6-1 | 210 |
| 32 (959) | Cesar Valentin | SS | Catalina Morales de Flore H.S. | 10/19/88 | R | R | 5-11 | 155 |
| 33 (989) | Ronald Clipp | RHP | Point Loma Nazarene U. (NM) | 8/15/84 | R | R | 6-3 | 185 |
| 34 (1019) | Nathan Samson | SS | Ocala Forest H.S. (FL) | 8/19/87 | R | R | 6-0 | 170 |
| 35 (1049) | Marquez Smith | 3B | Clemson University (FL) | 3/20/85 | R | R | 5-9 | 200 |
| 36 (1079) | Greibal Cuevas-Novas | RHP | Los Angeles Pierce College (CA) | 11/8/83 | R | R | 6-9 | 255 |
| 37 (1109) | Ross Francis | RHP | St. Joseph S.S. H.S. | 2/8/88 | R | R | 6-1 | 200 |
| 38 (1139) | Benjamin Feltner | CF | Temple College (TX) | 10/8/85 | S | R | 5-11 | 185 |
| 39 (1169) | Marcus Hatley | CF | Mission Hills H.S. (CA) | 3/26/88 | R | R | 6-4 | 190 |
| 40 (1199) | Eli Diaz | RHP | Texarkana C.C. (NY) | 11/11/86 | R | R | 6-3 | 180 |
| 41 (1229) | Jonathan Negron | RHP | Puerto Rico BB Academy H.S. | 8/14/88 | R | R | 6-3 | 182 |
| 42 (1259) | Benjamin Ornelas | OF | Cypress College (CA) | 11/8/86 | S | R | 6-2 | 210 |
| 43 (1288) | Anthony Morel | SS | Riverside C.C. (CA) | 7/29/87 | R | R | 6-1 | 175 |
| 44 (1317) | Daniel Berlind | RHP | Calabasas HS (CA) | 12/3/87 | R | R | 6-5 | 200 |
| 45 (1346) | Elliott Shea | CF | Franklin Pierce College (NH) | 4/12/84 | R | R | 6-0 | 200 |
| 46 (1375) | Ryan Shook | LHP | Valley Christian Academy HS (CA) | 10/17/88 | L | L | 5-11 | 170 |
| 47 (1403) | Andrew McCormick | RHP | Pikeville College (KY) | 8/9/84 | R | R | 6-6 | 210 |
| 48 (1431) | Kenneth Goodline | RHP | North Monterey County HS (CA) | 11/18/88 | R | R | 6-4 | 170 |
| 49 (1459) | Ryne Malone | 3B | Florida State University | 1/6/85 | L | R | 5-11 | 175 |
| 50 (1487) | Ryan Davis | LHP | Eastlake H.S. (WA) | 12/22/87 | L | L | 6-2 | 170 |